Morusin

Morusin is a prenylated flavonoid that has been found in M. alba and has diverse biological activities, including enzyme inhibitory, anti-inflammatory, and antiproliferative properties. It inhibits the UDP-glucuronosyltransferase (UGT) isoforms UGT1A6, UGT1A7, and UGT1A8 (IC50s = 4.23, 0.98, and 3 µM, respectively) and the cytochrome P450 (CYP) isoforms CYP3A4, CYP1A2, CYP2C9, and CYP2E1 (IC50s = 2.13, 1.27, 3.18, and 9.28 µM, respectively). Morusin (4 µM) inhibits histamine and leukotriene C4 (LTC4) production induced by A23187 (Cay-11016) and phorbol 12-myristate 13-acetate (PMA, Cay-10008014) in mouse MC/9 mast cells. It also inhibits the growth of MCF-7, MDA-MB-231, and MDA-MB-453 breast cancer cells (IC50s = 13.53, 10.84, and 11.99 µM, respectively). Morusin (12.5 mg/kg per day) decreases colonic tissue damage, TGF-beta1 levels, and matrix metalloproteinase-2 (MMP-2) and MMP-9 activity in a rat model of TNBS-induced ulcerative colitis.Formal Name: 2-(2,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-3-(3-methyl-2-buten-1-yl)-4H,8H-benzo[1,2-b:3,4-b']dipyran-4-one. CAS Number: 62596-29-6. Synonyms: Mulberrochromene, NSC 649220. Molecular Formula: C25H24O6. Formula Weight: 420.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 20mg/mL, DMF:PBS (pH 7.2) (1:3): 0.25mg/mL, DMSO: 10mg/mL, Ethanol: 15mg/mL. lambdamax: 271 nm. SMILES: OC1=CC=C(C(OC2=C3C(O)=CC4=C2C=CC(C)(C)O4)=C(C/C=C(C)/C)C3=O)C(O)=C1. InChi Code: InChI=1S/C25H24O6/c1-13(2)5-7-17-22(29)21-19(28)12-20-16(9-10-25(3,4)31-20)24(21)30-23(17)15-8-6-14(26)11-18(15)27/h5-6,8-12,26-28H,7H2,1-4H3. InChi Key: XFFOMNJIDRDDLQ-UHFFFAOYSA-N. Origin: Plant/Cortex mori.