Monascuspiloin

Monascuspiloin is a fungal metabolite that has been found in M. pilosus M93-fermented rice. It induces endoplasmic reticulum stress and autophagy in PC3 prostate cancer cells. Monascuspiloin (15-45 µM) decreases viability of PC3 cells and has an additive effect on the reduction in viability of PC3 cells induced by irradiation when used at a concentration of 25 µM. It induces intratumor apoptosis and autophagy and reduces tumor growth in a PC3 mouse xenograft model when administered at doses of 40 and 120 mg/kg.Formal Name: (3S,3aR,9aR)-3a,4,8,9a-tetrahydro-3-(1-hydroxyhexyl)-9a-methyl-6-(1E)-1-propen-1-yl-2H-furo[3,2-g][2]benzopyran-2,9(3H)-dione. CAS Number: 1011244-19-1. Synonyms: Monascinol. Molecular Formula: C21H28O5. Formula Weight: 360.4. Purity: >85%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Methanol: Soluble. SMILES: C[C@]12[C@@](CC3=C(COC(/C=C/C)=C3)C2=O)([H])[C@@H]([C@H](O)CCCCC)C(O1)=O. InChi Code: InChI=1S/C21H28O5/c1-4-6-7-9-17(22)18-16-11-13-10-14(8-5-2)25-12-15(13)19(23)21(16,3)26-20(18)24/h5,8,10,16-18,22H,4,6-7,9,11-12H2,1-3H3/b8-5+/t16-,17-,18+,21-/m1/s1. InChi Key: GNZJIIUXMNGZCY-IDIMIXOQSA-N. Origin: Fungus/Penicillium sp..