MMPSI

An inhibitor of caspase-3 and caspase-7 in a cell-free assay (IC50s = 0.085 and 1.3 µM, respectively), selective for caspase-3 and caspase-7 over caspase-1, -6, and -8 in a cell-free assay (IC50s = >15 µM), reduces ischemia-reperfusion injury-induced apoptosis in H9c2 rat cardiomyocytes (IC50 = 0.5 µM) and spontaneous apoptosis in adult rabbit cardiomyocyte isolates (IC50 = 1.5 µM), reduces infarct size in an isolated rabbit heart model of ischemia-reperfusion injury at 0.1, 1, and 10 µM. SMILES: O=C1C2=CC(S(=O)(N3[C@H](COC)CCC3)=O)=CC=C2NC1=O. InChi Code: InChI=1S/C14H16N2O5S/c1-21-8-9-3-2-6-16(9)22(19,20)10-4-5-12-11(7-10)13(17)14(18)15-12/h4-5,7,9H,2-3,6,8H2,1H3,(H,15,17,18)/t9-/m0/s1. InChi Key: SLQMNVJNDYLJSF-VIFPVBQESA-N