MMP-8 Inhibitor I

MMP-8 Inhibitor I is a selective inhibitor of the neutrophil collagenase matrix metalloproteinase-8 (MMP-8) with an IC50 value of 4 nM. This inhibitor does not target the activities of other MMPs in vitro. MMP-8 cleaves interstitial collagens and has exhibited activity in atherosclerotic plaques, angiogenesis, and stem cell mobilization. Additionally, MMP-8 expression is observed in normal mammary epithelial cells, whereas a loss of expression is observed in human ductal carcinoma in situ and the deletion of MMP-8 accelerates tumor onset in a mouse model of aggressive breast cancer.Formal Name: (3R)-1,2,3,4-tetrahydro-N-hydroxy-2-[(4-methoxyphenyl)sulfonyl]-3-isoquinolinecarboxamide. CAS Number: 236403-25-1. Synonyms: Matrix Metalloproteinase-8 Inhibitor I. Molecular Formula: C17H18N2O5S. Formula Weight: 362.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 200 mg/ml. SMILES: O=C(NO)[C@@H]1N(S(C2=CC=C(OC)C=C2)(=O)=O)CC3=CC=CC=C3C1. InChi Code: InChI=1S/C17H18N2O5S/c1-24-14-6-8-15(9-7-14)25(22,23)19-11-13-5-3-2-4-12(13)10-16(19)17(20)18-21/h2-9,16,21H,10-11H2,1H3,(H,18,20)/t16-/m1/s1. InChi Key: PPELJLBDXLMTEW-MRXNPFEDSA-N.