ML-115

Signal transducer and activator of transcription 3 (STAT3) is a cytokine-inducible transcription factor with roles in inflammation and cancer. ML-115 is an isoxazole carboxamide that acts as a cell-permeable STAT3 activator (EC50 = 2 nM) and is more than 28,000-fold selective for STAT3 over STAT1 and NF-kappaB. It shows no cytotoxicity against HT-1080 or NIH-3T3 cells. ML-115 increases the expression of BCL3, a known STAT3-dependent oncogene, and enhances STAT3 activation by the pro-inflammatory cytokine IL-6. As the maintenance of pluripotency in mouse embryonic stem cells requires continued activation of STAT3, ML-115 may be useful in maintaining embryonic stem cells in an undifferentiated state.Formal Name: N-(4-chloro-2,5-dimethoxyphenyl)-5-cyclopropyl-3-isoxazolecarboxamide. CAS Number: 912798-42-6. Synonyms: CID-6619100, SID 14735210. Molecular Formula: C15H15ClN2O4. Formula Weight: 322.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 16 mg/ml, Ethanol: 0.1 mg/ml. lambdamax: 236, 317 nm. SMILES: COC1=CC(NC(C2=NOC(C3CC3)=C2)=O)=C(OC)C=C1Cl. InChi Code: InChI=1S/C15H15ClN2O4/c1-20-13-6-10(14(21-2)5-9(13)16)17-15(19)11-7-12(22-18-11)8-3-4-8/h5-8H,3-4H2,1-2H3,(H,17,19). InChi Key: FMWABCRYNLCXOJ-UHFFFAOYSA-N.