ML-SA5

ML-SA5 is an agonist of transient receptor potential mucolipin 1 (TRPML1). It activates whole-endolysosome TRPML1-mediated current (IML1) in isolated vacuoles that were enlarged by vacuolin-1 (Cay-20425) (EC50 = 333 nM). ML-SA5 (3 µM) is cytotoxic to MeWo and M12 melanoma cells but not normal melanocytes. It induces gastric acid secretion in isolated stomach from wild-type but not TRPML1-/- mice. ML-SA5 (2 and 5 mg/kg) decreases the necrotic area and percentage of centrally nucleated fibers in the dystrophin-deficient mdx mouse model of Duchenne muscular dystrophy.Formal Name: N4-[3-chloro-2-(1-piperidinyl)phenyl]-N1,N1-dimethyl-1,4-benzenedisulfonamide. CAS Number: 2418670-70-7. Synonyms: Mucolipin Synthetic Agonist 5. Molecular Formula: C19H24ClN3O4S2. Formula Weight: 458.0. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. SMILES: O=S(NC1=C(N2CCCCC2)C(Cl)=CC=C1)(C3=CC=C(S(=O)(N(C)C)=O)C=C3)=O. InChi Code: InChI=1S/C19H24ClN3O4S2/c1-22(2)29(26,27)16-11-9-15(10-12-16)28(24,25)21-18-8-6-7-17(20)19(18)23-13-4-3-5-14-23/h6-12,21H,3-5,13-14H2,1-2H3. InChi Key: YPPWKTIVYUTTEH-UHFFFAOYSA-N.