ML-354

ML-354 is an indole-based, proteinase-activated receptor 4 (PAR4) antagonist (IC50 = 140 nM) that exhibits 71-fold selectivity for PAR4 over PAR1 (IC50 = 10 µM) in isolated human platelets.Formal Name: 1-methyl-5-nitro-3-phenyl-1H-indole-2-methanol. CAS Number: 89159-60-4. Synonyms: VU0099704. Molecular Formula: C16H14N2O3. Formula Weight: 282.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml, DMSO: 20 mg/ml, Ethanol: 2 mg/ml. lambdamax: 263, 280 nm. SMILES: CN1C(CO)=C(C2=CC=CC=C2)C3=C1C=CC([N+]([O-])=O)=C3. InChi Code: InChI=1S/C16H14N2O3/c1-17-14-8-7-12(18(20)21)9-13(14)16(15(17)10-19)11-5-3-2-4-6-11/h2-9,19H,10H2,1H3. InChi Key: GNJUKVGDCUKDLF-UHFFFAOYSA-N.