ML-349

ML-349 is a selective and reversible inhibitor of lysophospholipase 2 (LYPLA2, Kis = 230 and >10,000 nM for human recombinant LYPLA2 and LYPLA1, respectively). Treatment with ML-349 results in >95% inhibition of LYPLA2 with no change in the activity of 25 other serine hydrolases in BW5147 murine T cell hybridoma cells. ML-349 almost completely inhibits LYPLA2 in HEK293T and mouse T cells and in vivo in murine lung, heart, and kidneys. It partially inhibits LYPLA2 in murine brain.Formal Name: (5,5-dioxido-4H-thieno[3,2-c][1]benzothiopyran-2-yl)[4-(4-methoxyphenyl)-1-piperazinyl]-methanone. CAS Number: 890819-86-0. Molecular Formula: C23H22N2O4S2. Formula Weight: 454.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml. lambdamax: 242, 319 nm. SMILES: COC1=CC=C(N2CCN(C(C3=CC(CS(C4=CC=CC=C45)(=O)=O)=C5S3)=O)CC2)C=C1. InChi Code: InChI=1S/C23H22N2O4S2/c1-29-18-8-6-17(7-9-18)24-10-12-25(13-11-24)23(26)20-14-16-15-31(27,28)21-5-3-2-4-19(21)22(16)30-20/h2-9,14H,10-13,15H2,1H3. InChi Key: YVIJPELUPZUEJX-UHFFFAOYSA-N.