ML 297
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: ML 297 is a selective Kir3.1/3.2 (GIRK1/2) channel activator (IC50 values are 160,... more
Product information "ML 297"
Description: ML 297 is a selective Kir3.1/3.2 (GIRK1/2) channel activator (IC50 values are 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively). ML 297 exhibits no effect on GIRK2, GIRK2/3, Kir2.1 and Kv7.4 channels, and has minimal effect on a panel of other ion channels, receptors and transporters. Target: Potassium Channel. Smiles: Cc1cc(NC(=O)Nc2ccc(F)c(F)c2)n(n1)-c1ccccc1. References: Wydeven N, Marron Fernandez de Velasco E, Du Y, Benneyworth MA, Hearing MC, Fischer RA, Thomas MJ, Weaver CD, Wickman K. Mechanisms underlying the activation of G-protein-gated inwardly rectifying K+ (GIRK) channels by the novel anxiolytic drug, ML297. Proc Natl Acad Sci U S A. 2014 Jul 22,111(29):10755-60.
| Keywords: | ML297 |
| Supplier: | TargetMol |
| Supplier-Nr: | T4664 |
Properties
| Application: | GIRK1/2 activator |
| MW: | 328.32 D |
| Formula: | C17H14F2N4O |
Database Information
| CAS : | 1443246-62-5| Matching products |
| KEGG ID : | K04997 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H410 |
| P Phrases: | P273, P391, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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