ML-191

ML-191 is an antagonist of GPR55. It inhibits GPR55 signaling induced by lysophosphatidylinositol (LPI, EC50 = 1.076 µM in U2OS cells overexpressing GPR55). ML-191 inhibits LPI-induced phosphorylation of ERK1/2 (IC50 = 328 nM) and receptor-dependent translocation of PKCbetaII when used at a concentration of 30 µM.Formal Name: 5-phenyl-3-(1-(1-(p-tolyl)cyclopropane-1-carbonyl)piperidin-4-yl)-1,3,4-oxadiazol-2(3H)-one. CAS Number: 931695-79-3. Synonyms: CCG-152883, CID-23612552. Molecular Formula: C24H25N3O3. Formula Weight: 403.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 5 mg/ml. lambdamax: 269 nm. SMILES: CC1=CC=C(C2(CC2)C(N3CCC(N4N=C(C5=CC=CC=C5)OC4=O)CC3)=O)C=C1. InChi Code: InChI=1S/C24H25N3O3/c1-17-7-9-19(10-8-17)24(13-14-24)22(28)26-15-11-20(12-16-26)27-23(29)30-21(25-27)18-5-3-2-4-6-18/h2-10,20H,11-16H2,1H3. InChi Key: WWJKJCDOYFKZBJ-UHFFFAOYSA-N.