ML-141

Cdc42 is a member of the Rho GTPase subfamily that has roles in cytoskeleton organization, cell cycle progression, signal transduction, and vesicle trafficking. It cycles between a GTP-bound active state and a GDP-bound inactive state. ML-141 is a noncompetitive, allosteric inhibitor of Cdc42 (EC50 = 2.1 µM) with no inhibitory action against Rho, Ras, Rab, or Rac. It also inhibits the constitutively active Cdc42 Q61L mutant (EC50 = 2.6 µM). ML-141 blocks Cdc42-dependent filopodia formation in 3T3 cells and migration of ovarian cancer cells, prevents Cdc42-regulated virus infection, and inhibits the signaling pathway of VLA-4 integrin. It is a useful tool to interrogate the role of Cdc42 intracellular signaling and cell activity.Formal Name: 4-[4,5-dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]-benzenesulfonamide. CAS Number: 71203-35-5. Synonyms: CID-2950007. Molecular Formula: C22H21N3O3S. Formula Weight: 407.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml, DMSO: 20 mg/ml. lambdamax: 229, 274, 357 nm. SMILES: NS(C(C=C1)=CC=C1N2C(C3=CC=C(OC)C=C3)CC(C4=CC=CC=C4)=N2)(=O)=O. InChi Code: InChI=1S/C22H21N3O3S/c1-28-19-11-7-17(8-12-19)22-15-21(16-5-3-2-4-6-16)24-25(22)18-9-13-20(14-10-18)29(23,26)27/h2-14,22H,15H2,1H3,(H2,23,26,27). InChi Key: QBNZBMVRFYREHK-UHFFFAOYSA-N.