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Description: MKT-077 (FJ-776) is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines (EC50s: 1.4-2.2 µM in vitro) through its ability to inhibit members of the Hsp70 family of molecular chaperones. Target: HSP. Smiles: [Cl-].CCn1\c(=C\c2cccc[n+]2CC)s\c(=C2/Sc3ccccc3N2C)c1=O. References: Starenki D, et al. Selective Mitochondrial Uptake of MKT-077 Can Suppress Medullary Thyroid Carcinoma Cell Survival In Vitro and In Vivo. Endocrinol Metab (Seoul). 2015 Dec,30(4):593-603.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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