MK2 Inhibitor IV

Activation of the p38/mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2 or MK2) pathway has been implicated in promoting pro-inflammatory cytokine production and related inflammatory diseases. MK2 inhibitor IV is a highly selective, non-ATP competitive MK2 inhibitor with an IC50 value of 0.11 µM. MK2 inhibitor IV has been shown to inhibit pro-inflammatory cytokine secretion from the human THP-1 acute monocytic leukemia cell line, causing inhibition of LPS-stimulated TNF-alpha (IC50 = 4.4 µM) and IL-6 (IC50 = 5.2 µM) secretion. It can also inhibit IL-1beta-stimulated matrixmetalloprotease 13 secretion from the SW1353 chondrosarcoma cell line (IC50 = 5.7 µM) and human primary chondrocyte cultures (IC50 = 2.2 µM).Formal Name: 5-(4-chlorophenyl)-N-[4-(1-piperazinyl)phenyl]-N-(2-pyridinylmethyl)-2-furancarboxamide, monohydrochloride. CAS Number: 1314118-94-9. Synonyms: MK 25. Molecular Formula: C27H25ClN4O2 . HCl. Formula Weight: 509.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 1 mg/ml. lambdamax: 256, 312 nm. SMILES: O=C(N(C1=CC=C(N2CCNCC2)C=C1)CC3=NC=CC=C3)C4=CC=C(C5=CC=C(Cl)C=C5)O4.Cl. InChi Code: InChI=1S/C27H25ClN4O2.ClH/c28-21-6-4-20(5-7-21)25-12-13-26(34-25)27(33)32(19-22-3-1-2-14-30-22)24-10-8-23(9-11-24)31-17-15-29-16-18-31,/h1-14,29H,15-19H2,1H. InChi Key: AZDOSXSDARWKGX-UHFFFAOYSA-N.