MK-5108

The Aurora kinases are a family of serine/threonine kinases that are key regulators of mitosis and cytokinesis. MK-5108 is a potent inhibitor of Aurora A (IC50 = 0.064 nM). It less potently inhibits Aurora B and Aurora C (IC50s =14 and 12 nM, respectively). MK-5108 blocks cell cycle progression and induces apoptosis in a diverse range of human tumor types. It is effective in vivo, inhibiting the growth of xenograft tumors in mice.Formal Name: trans-4-(3-chloro-2-fluorophenoxy)-1-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]-cyclohexanecarboxylic acid. CAS Number: 1010085-13-8. Synonyms: VX-689. Molecular Formula: C22H21ClFN3O3S. Formula Weight: 461.9. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMF:PBS (pH7.2) (1:30): 0.025 mg/ml, DMSO: 2 mg/ml. lambdamax: 278, 310 nm. SMILES: ClC1=C(F)C(O[C@@H]2CC[C@@](CC3=CC=CC(NC4=NC=CS4)=N3)(C(O)=O)CC2)=CC=C1. InChi Code: InChI=1S/C22H21ClFN3O3S/c23-16-4-2-5-17(19(16)24)30-15-7-9-22(10-8-15,20(28)29)13-14-3-1-6-18(26-14)27-21-25-11-12-31-21/h1-6,11-12,15H,7-10,13H2,(H,28,29)(H,25,26,27)/t15-,22-. InChi Key: LCVIRAZGMYMNNT-VVONHTQRSA-N.