MitoPBN

MitoPBN is a mitochondria-targeted antioxidant. It accumulates in the mitochondria following the generation of a mitochondrial membrane potential by succinate, an effect that is blocked by addition of the mitochondrial membrane potential uncoupler FCCP (Cay-15218). MitoPBN inhibits superoxide activation of mitochondrial uncoupling protein 1 (UCP1), UCP2, and UCP3 when used at a concentration of 250 nM in vitro but does not react with superoxide. It traps hydroxyl (IC50 = ~77 µM) and carbon-centered radicals and inhibits the initiation of lipid peroxidation in isolated bovine heart mitochondria.Formal Name: [4-[4-[[(1,1-dimethylethyl)oxidoimino]methyl]phenoxy]butyl]triphenyl-phosphonium, monobromide. CAS Number: 652968-37-1. Molecular Formula: C33H37NO2P . Br. Formula Weight: 590.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 25 mg/ml, DMF:PBS(pH7.2) (1:2): 0.33 mg/ml, DMSO: 1 mg/ml, Ethanol: 0.33 mg/ml. lambdamax: 303, 406, 659 nm. SMILES: CC(C)(C)/[N+]([O-])=C/C(C=C1)=CC=C1OCCCC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4.[Br-]. InChi Code: InChI=1S/C33H37NO2P.BrH/c1-33(2,3)34(35)27-28-21-23-29(24-22-28)36-25-13-14-26-37(30-15-7-4-8-16-30,31-17-9-5-10-18-31)32-19-11-6-12-20-32,/h4-12,15-24,27H,13-14,25-26H2,1-3H3,1H/q+1,/p-1/b34-27-,. InChi Key: JZMWLDMVLIVXEF-KWYZZNRTSA-M.