Mitoguazone

Mitoguazone is an inhibitor of S-adenosylmethionine decarboxylase (SAMDC) and diamine oxidase (DAO, IC50s = 1 and 0. µM for the rat and porcine enzymes, respectively). It inhibits viral DNA integration and replication in HIV-1-infected primary human macrophages when used at a concentration of 0. µM. Mitoguazone (10 µM) decreases viability and induces mitochondrial swelling and cristae degradation in L1210 murine skin lymphocytic leukemia cells. It reduces the proliferation of seven melanoma cancer cell lines (IC50s = 0.09-6. µM). In vivo, mitoguazone (50 mg/kg per day), in combination with a-difluoromethylornithine (DFMO, Cay-16889), decreases tumor weight in a patient-derived xenograft (PDX) mouse model of differentiated papillary adenocarcinoma.InChI: InChI=1S/C5H12N8/c1-3(11-13-5(8)9)2-10-12-4(6)7/h2H,1H3,(H4,6,7,12)(H4,8,9,13) InChIKey: MXWHMTNPTTVWDM-UHFFFAOYSA-N SMILES: N=C(NN=CC(C)=NNC(N)=N)N