Miltirone

Miltirone is a tanshinone that has been found in S. miltiorrhiza and has diverse biological activities. It protects lard from thermal oxidation when used at a concentration of 0.02%. Miltirone is a partial agonist of the benzodiazepine receptor (IC50 = 0.3 µM). It inhibits carboxylesterase 2 (CES2, Ki = 0.04 µM) as well as severe acute respiratory syndrome coronavirus (SARS-CoV) main protease (Mpro), also known as 3C-like protease (3CLpro), and papain-like protease (PLpro, IC50s = 21.1 and 30 µM, respectively). Miltirone is cytotoxic to HCT116 colon cancer cells (IC50 = 4.27 µM) and induces mitochondrial dysfunction and the production of reactive oxygen species (ROS) in the same cells. In vivo, miltirone (10-60 mg/kg) increases the number of punished crossings in the four-plate test, indicating tranquilizing activity, in mice.Formal Name: 5,6,7,8-tetrahydro-8,8-dimethyl-2-(1-methylethyl)-3,4-phenanthrenedione. CAS Number: 27210-57-7. Synonyms: NSC 639662, Rosmariquinone. Molecular Formula: C19H22O2. Formula Weight: 282.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: soluble, Ethyl Acetate: soluble. lambdamax: 258 nm. SMILES: O=C1C(C(C(C)C)=CC2=C1C(CCCC3(C)C)=C3C=C2)=O. InChi Code: InChI=1S/C19H22O2/c1-11(2)14-10-12-7-8-15-13(6-5-9-19(15,3)4)16(12)18(21)17(14)20/h7-8,10-11H,5-6,9H2,1-4H3. InChi Key: FEFAIBOZOKSLJR-UHFFFAOYSA-N. Origin: Synthetic.