Mezlocillin (sodium salt)

Mezlocillin is a beta-lactam antibiotic and derivative of ampicillin (Cay-14417). It is active against B. fragilis, E. lentum, P. morbillorum, and F. nucleatum (MICs = 8, 4, 2, and 4 µg/ml, respectively). Mezlocillin (32 µg/ml) is also active against 10 strains of S. faecalis. In vivo, mezlocillin (240 mg/kg) increases survival and reduces bacteremia in a rabbit model of S. faecalis endocarditis. It completely eliminates lung P. morbillorum, E. lentum, and F. nucelatum, but not B. fragilis, in a rabbit model of pulmonary P. morbillorum, E. lentum, F. nucelatum, and B. fragilis infection when administered at a dose of 300 mg/kg. Formulations containing mezlocillin have been used in the treatment of various bacterial infections.Formal Name: [2S-[2alpha,5alpha,6beta(S*)]]-3,3-dimethyl-6-[[[[[[[3-(methylsulfonyl)-2-oxo-1-imidazolidinyl]carbonyl]amino]carbonyl]amino]phenylacetyl]amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, monosodium salt. CAS Number: 59798-30-0. Molecular Formula: C22H25N6O9S2 . Na. Formula Weight: 604.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: O=C(N1CCN(S(C)(=O)=O)C1=O)NC(N[C@H](C2=CC=CC=C2)C(N[C@@H]3C(N4[C@]3([H])SC(C)(C)[C@@H]4C([O-])=O)=O)=O)=O.[Na+]. InChi Code: InChI=1S/C22H26N6O9S2.Na/c1-22(2)14(18(31)32)28-16(30)13(17(28)38-22)23-15(29)12(11-7-5-4-6-8-11)24-19(33)25-20(34)26-9-10-27(21(26)35)39(3,36)37,/h4-8,12-14,17H,9-10H2,1-3H3,(H,23,29)(H,31,32)(H2,24,25,33,34),/q,+1/p-1/t12-,13-,14+,17-,/m1./s1. InChi Key: SDQBKOKICLGDOA-ZBJAFUORSA-M.