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Metyrosine is an inhibitor of tyrosine hydroxylase. In vivo, metyrosine (200 mg/kg) reduces norepinephrine and dopamine levels in rat brain and disrupts conditioned avoidance behavior in a dose-dependent manner. Metyrosine reduces dopamine transporter knockdown-induced hyperactivity and rearing behavior and increases exploratory behavior in a hole board assay in a mouse model of bipolar disorder mania. It reduces hypertension induced by dexamethasone (Cay-11015) and cyclosporin in rats. Metyrosine also inhibits norepinephrine production and increases plasma levels of leptin in fasted and fed mice.Formal Name: alpha-methyl-L-tyrosine. CAS Number: 672-87-7. Synonyms: alpha-Methyl-L-p-tyrosine, MK-781, L-alpha-MT. Molecular Formula: C10H13NO3. Formula Weight: 195.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: <50 µg/ml, DMSO: <50 µg/ml, Ethanol: <50 µg/ml, PBS (pH 7.2): >2 mg/ml. SMILES: OC1=CC=C(C[C@](N)(C)C(O)=O)C=C1. InChi Code: InChI=1S/C10H13NO3/c1-10(11,9(13)14)6-7-2-4-8(12)5-3-7/h2-5,12H,6,11H2,1H3,(H,13,14)/t10-/m1/s1. InChi Key: NHTGHBARYWONDQ-SNVBAGLBSA-N.
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