meso-2,3-Dimercaptosuccinic Acid

meso-2,3-Dimercaptosuccinic acid is a heavy metal chelator. It reverses sodium arsenite-induced inhibition of pyruvate dehydrogenase (PDH) in mouse kidney homogenates (EC50 = 0.25 mM). meso-2,3-Dimercaptosuccinic acid decreases cisplatin-induced increases in serum levels of platinum and blood urea nitrogen (BUN), as well as apoptosis in renal tubules of mice when administered at a dose of 100 µM/kg. meso-2,3-Dimercaptosuccinic acid (90 mg/kg) decreases elevations in the activity of catalase and glucose-6-phosphate dehydrogenase (G6PDH) in RBCs from lead-exposed rats, and decreases the levels of lead in the cerebellum, hippocampus, liver, kidney, and blood in rats when administered at a dose of 100 mg/kg. It decreases immobility time in the forced swim test in lead-exposed male, but not female, mice when administered at a dose of 50 mg/kg. Formulations containing meso-2,3-dimercaptosuccinic acid have been used in the treatment of heavy metal poisoning.Formal Name: (2R,3S)-rel-2,3-dimercapto-butanedioic acid. CAS Number: 304-55-2. Synonyms: DMSA, Succimer. Molecular Formula: C4H6O4S2. Formula Weight: 182.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10mg/ml, DMSO: 10 mg/ml, DMSO:PBS (pH 7.2) (1:8): 0.1 mg/ml. SMILES: OC([C@@H](S)[C@@H](S)C(O)=O)=O. InChi Code: InChI=1S/C4H6O4S2/c5-3(6)1(9)2(10)4(7)8/h1-2,9-10H,(H,5,6)(H,7,8)/t1-,2+. InChi Key: ACTRVOBWPAIOHC-XIXRPRMCSA-N.