Mer-NF5003F

Mer-NF5003F is a sesquiterpene originally isolated from Stachybotrys with diverse biological activities. It inhibits avian myeloblastosis virus (AMV) protease (IC50 = 7.8 µM). Mer-NF5003F inhibits sialyltransferase 6N (ST6N), ST3O, and ST3N (IC50s = 0.61, 6.7, and 10 µg/ml, respectively), as well as fucosyltransferase (IC50 = 11.3 µg/ml). It is active against herpes simplex virus 1 (HSV-1) in vitro (IC50 = 4.32 µg/ml). Mer-NF5003F is also active against the multidrug-resistant P. falciparum strain K1 (IC50 = 0.85 µg/ml).Formal Name: (1'R,2'R,4'aS,6'R,8'aS)-3',4',4'a,5',6',7',8',8'a-octahydro-4,6'-dihydroxy-2',5',5',8'a-tetramethyl-spiro[benzofuran-2(3H),1'(2'H)-naphthalene]-6,7-dicarboxaldehyde. CAS Number: 149598-70-9. Synonyms: F 1839M, NF 5003F, Stachybotrydial. Molecular Formula: C23H30O5. Formula Weight: 386.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: soluble, DMSO: soluble, Ethanol: soluble, Methanol: soluble. SMILES: O[C@@H]1CC[C@@]2(C)[C@](CC[C@@H](C)[C@@]23OC(C(C=O)=C(C=O)C=C4O)=C4C3)([H])C1(C)C. InChi Code: InChI=1S/C23H30O5/c1-13-5-6-18-21(2,3)19(27)7-8-22(18,4)23(13)10-15-17(26)9-14(11-24)16(12-25)20(15)28-23/h9,11-13,18-19,26-27H,5-8,10H2,1-4H3/t13-,18+,19-,22+,23-/m1/s1. InChi Key: WIGGVNIABVHHCS-QJAXDWLUSA-N. Origin: Fungus/Stachybotrys sp..