Melperone (hydrochloride)

Melperone is an atypical antipsychotic. It binds to alpha1- and alpha2-adrenergic and dopamine D2 receptors (Kds = 180, 150, and 180 nM, respectively), as well as the serotonin (5-HT) receptor subtype 5-HT2A (Kd = 102 nM). It is selective for these receptors over histamine H1, muscarinic, 5-HT1A, 5-HT1D, and 5-HT2C receptors (Kds = 580, >10,000, 2,200, 3,400, and 2,100 nM, respectively). Melperone (2 mg/kg per day) increases basal, but not amphetamine-induced, extracellular dopamine levels in the rat nucleus accumbens.Formal Name: 1-(4-fluorophenyl)-4-(4-methyl-1-piperidinyl)-1-butanone, monohydrochloride. CAS Number: 1622-79-3. Synonyms: FG 5111, Methylperone. Molecular Formula: C16H22FNO . HCl. Formula Weight: 299.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/mL, DMSO: 20 mg/mL, Ethanol: 20 mg/mL, PBS (pH 7.2): 2 mg/mL. lambdamax: 245, 337 nm. SMILES: FC1=CC=C(C(CCCN2CCC(C)CC2)=O)C=C1.Cl. InChi Code: InChI=1S/C16H22FNO.ClH/c1-13-8-11-18(12-9-13)10-2-3-16(19)14-4-6-15(17)7-5-14,/h4-7,13H,2-3,8-12H2,1H3,1H. InChi Key: MQHYXXIJLKFQGY-UHFFFAOYSA-N.