Meisoindigo

Meisoindigo is a derivative of indirubin (Cay-14155) that has anticancer activity. It inhibits the growth of NB4, HL-60, and U937 leukemia and primary acute myeloid leukemia (AML) cells when used at concentrations of 5 and 10 µM. It also halts the cell cycle at the G0/G1 phase and induces apoptosis in leukemia cell lines and primary AML cells, induces myeloid differentiation, and potentiates the effects of cytarabine (Cay-16069) and idarubicin (Cay-14176). Meisoindigo (10 µM) also induces apoptosis, decreases adherence, and decreases the expression of vascular cell adhesion molecule-1 (VCAM-1) in ECV304 human vein endothelial cells. Meisoindigo (50-150 mg/kg per day) decreases spleen size in an HL-60 mouse xenograft model of AML in a dose-dependent manner.Formal Name: 3-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)-1,3-dihydro-1-methyl-2H-indol-2-one. CAS Number: 97207-47-1. Synonyms: Methylisoindigotin. Molecular Formula: C17H12N2O2. Formula Weight: 276.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 16 mg/ml, DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml, DMSO: 1 mg/ml. lambdamax: 270, 388 nm. SMILES: CN(C1=CC=CC=C1/C2=C3C(NC4=C\3C=CC=C4)=O)C2=O. InChi Code: InChI=1S/C17H12N2O2/c1-19-13-9-5-3-7-11(13)15(17(19)21)14-10-6-2-4-8-12(10)18-16(14)20/h2-9H,1H3,(H,18,20)/b15-14+. InChi Key: QNOCRUSVMMAKSC-CCEZHUSRSA-N.