Mefenamic Acid

Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and a COX-2 inhibitor. It binds to COX-2 (Kd = 4 nM) and inhibits COX-2-dependent oxygenation of arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) in vitro (Ki = 10 µM). Mefenamic acid (30 mg/kg) reduces acetic acid-induced writhing in rats. It inhibits increases in skin thickness in a mouse model of delayed-type hypersensitivity induced by dinitrochlorobenzene (DNBC). Mefenamic acid also reduces the antibody response to sheep red blood cells in mice.Formal Name: 2-[(2,3-dimethylphenyl)amino]-benzoic acid. CAS Number: 61-68-7. Synonyms: C.I. 473, CN 35355, NSC 94437. Molecular Formula: C15H15NO2. Formula Weight: 241.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly Soluble, Methanol: Slightly Soluble. SMILES: CC1=CC=CC(NC2=CC=CC=C2C(O)=O)=C1C. InChi Code: InChI=1S/C15H15NO2/c1-10-6-5-9-13(11(10)2)16-14-8-4-3-7-12(14)15(17)18/h3-9,16H,1-2H3,(H,17,18). InChi Key: HYYBABOKPJLUIN-UHFFFAOYSA-N.