Mecillinam

Description: Mecillinam (Hexacillin), an extended-spectrum penicillin antibiotic, is considered to be active against Gram-negative bacteria by binding specifically to penicillin-binding protein 2 (PBP2). It is used primarily to treat urinary tract infections and has also been used in the treatment of paratyphoid fever and typhoid. Target: Antibacterial. Smiles: [H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2\N=C\N1CCCCCC1)C(O)=O. References: Thulin E, Sundqvist M, Andersson DI. Amdinocillin (Mecillinam) resistance mutations in clinical isolates and laboratory-selected mutants of Escherichia coli. Antimicrob Agents Chemother. 2015 Mar,59(3):1718-27.