MD-224

Description: MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent. Target: Mdm2, E1/E2/E3 Enzyme, PROTACs. Smiles: O=C1[C@@]2([C@]3(N[C@@H](C(NC4=CC=C(C(NCCCC#CC5=C6C(C(=O)N(C6)C7C(=O)NC(=O)CC7)=CC=C5)=O)C=C4)=O)[C@@H]2C8=C(F)C(Cl)=CC=C8)CCCCC3)C=9C(N1)=CC(Cl)=CC9. References: Li Y, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis TargetingChimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable TumorRegression. J Med Chem. 2019 Jan 24,62(2):448-466