McNA343

McNA343 is a partial agonist of muscarinic acetylcholine receptors (Kis = 5, 1, 5, 0.2, and 7.6 µM for M1-5 receptors, respectively, in radioligand binding assays). It induces contraction of isolated human umbilical veins (EC50 = 1.23 µM), an effect that can be reversed by various M1 muscarinic receptor selective antagonists. McNA343 also inhibits forskolin-induced cAMP production in CHO cells expressing M1 or M4 receptors, as well as phosphatidylinositol hydrolysis in CHO-K1 cells expressing M3 receptors and CHO cells expressing M5 receptors. Intrathecal administration of McNA343 inhibits compulsive hindlimb neck-scratching behavior induced by 5'-guanidinonaltrindole (GNTI) in mice. It has nootropic activity, enhancing spontaneous working memory in the Y maze in wild-type mice, and it reverses learning and memory impairments induced by bulbectomy in mice in a passive avoidance test.Formal Name: 4-[[[(3-chlorophenyl)amino]carbonyl]oxy]-N,N,N-trimethyl-2-butyn-1-aminium, monochloride. CAS Number: 55-45-8. Molecular Formula: C14H18ClN2O2 . Cl. Formula Weight: 317.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 15mg/mL, DMSO: 25mg/mL, Ethanol: 15mg/mL, PBS (pH 7.2): 10mg/mL. lambdamax: 239 nm. SMILES: ClC1=CC=CC(NC(OCC#CC[N+](C)(C)C)=O)=C1.[Cl-]. InChi Code: InChI=1S/C14H17ClN2O2.ClH/c1-17(2,3)9-4-5-10-19-14(18)16-13-8-6-7-12(15)11-13,/h6-8,11H,9-10H2,1-3H3,1H. InChi Key: CXFZFEJJLNLOTA-UHFFFAOYSA-N.