Mca-VDQVDGW-K(Dnp)-NH2

Mca-VDQVDGW-K(Dnp)-NH2 is a substrate for caspase-7. Upon cleavage by caspase-7, 7-methoxycoumarin-4-acetyl (Mca) is released and its fluorescence can be used to quantify caspase-7 activity. Mca displays excitation/emission maxima of 328/420 nm, respectively.Formal Name: (3S,6S,9S,12S,18S,21S)-18-((1H-indol-3-yl)methyl)-6-(3-amino-3-oxopropyl)-21-carbamoyl-12-(carboxymethyl)-25-((2,4-dinitrophenyl)amino)-9-isopropyl-3-((S)-2-(2-(7-methoxy-2-oxo-2H-chromen-4-yl)acetamido)-3-methylbutanamido)-4,7,10,13,16,19-hexaoxo-5,8,11,14,17,20-hexaazapentacosanoic acid. Synonyms: Caspase-7 Fluorogenic Substrate I, Mca-VDQVDGW-Lys(Dnp)-NH2. Molecular Formula: C60H74N14O21. Formula Weight: 1327.3. Purity: >95%. Formulation: (Request formulation change), A lyophilized powder. Solubility: Water: 1 mg/ml. SMILES: NC([C@@H](NC([C@H](CC1=CNC2=C1C=CC=C2)NC(CNC([C@H](CC(O)=O)NC([C@@H](NC([C@@H](NC([C@H](CC(O)=O)NC([C@@H](NC(CC3=CC(OC4=C3C=CC(OC)=C4)=O)=O)C(C)C)=O)=O)CCC(N)=O)=O)C(C)C)=O)=O)=O)=O)CCCCNC5=CC=C([N+]([O-])=O)C=C5[N+]([O-])=O)=O. InChi Code: InChI=1S/C60H74N14O21/c1-29(2)52(71-47(76)21-31-22-51(82)95-45-24-34(94-5)14-15-36(31)45)59(88)70-43(26-50(80)81)58(87)68-40(17-18-46(61)75)56(85)72-53(30(3)4)60(89)69-42(25-49(78)79)55(84)65-28-48(77)66-41(20-32-27-64-37-11-7-6-10-35(32)37)57(86)67-39(54(62)83)12-8-9-19-63-38-16-13-33(73(90)91)23-44(38)74(92)93/h6-7,10-11,13-16,22-24,27,29-30,39-43,52-53,63-64H,8-9,12,17-21,25-26,28H2,1-5H3,(H2,61,75)(H2,62,83)(H,65,84)(H,66,77)(H,67,86)(H,68,87)(H,69,89)(H,70,88)(H,71,76)(H,72,85)(H,78,79)(H,80,81)/t39-,40-,41-,42-,43-,52-,53-/m0/s1. InChi Key: IAEXPKQPOUYJTI-GEXOKMAJSA-N.