Mca-SEVNLDAEFR-K(Dnp)-RR-NH2 (acetate)

Mca-SEVNLDAEFR-K(Dnp)-RR-NH2 is a fluorogenic substrate for beta-secretase (BACE). Upon cleavage by BACE, 7-methoxycoumarin-4-acetyl (Mca) is released and its fluorescence can be used to quantify BACE activity. Mca displays excitation/emission maxima of 328/420 nm, respectively.Formal Name: N-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-seryl-L-alpha-glutamyl-L-valyl-L-asparaginyl-L-leucyl-L-alpha-aspartyl-L-alanyl-L-alpha-glutamyl-L-phenylalanyl-L-arginyl-N6-(2,4-dinitrophenyl)-L-lysyl-L-arginyl-L-argininamide, acetate. Molecular Formula: C86H125N27O29 . XC2H4O2. Formula Weight: 2001.1. Purity: >95%. Emission: 420 nm. Excitation: 328 nm. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. SMILES: N=C(N)NCCC[C@@H](C(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCNC1=C(C=C(C=C1)[N+]([O-])=O)[N+]([O-])=O)NC([C@H](CCCNC(N)=N)NC([C@H](CC2=CC=CC=C2)NC([C@H](CCC(O)=O)NC([C@H](C)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@H](CC(N)=O)NC([C@H](C(C)C)NC([C@H](CCC(O)=O)NC([C@H](CO)NC(CC(C3=CC=C(OC)C=C3O4)=CC4=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C)=O. InChi Code: InChI=1S/C86H125N27O29.C2H4O2/c1-42(2)33-57(107-81(134)59(39-64(87)115)110-83(136)70(43(3)4)111-77(130)56(26-28-67(119)120)106-82(135)61(41-114)100-65(116)35-46-36-69(123)142-63-38-48(141-6)22-23-49(46)63)79(132)109-60(40-68(121)122)78(131)99-44(5)72(125)102-55(25-27-66(117)118)76(129)108-58(34-45-15-8-7-9-16-45)80(133)105-54(20-14-32-98-86(93)94)75(128)103-52(17-10-11-29-95-50-24-21-47(112(137)138)37-62(50)113(139)140)74(127)104-53(19-13-31-97-85(91)92)73(126)101-51(71(88)124)18-12-30-96-84(89)90,1-2(3)4/h7-9,15-16,21-24,36-38,42-44,51-61,70,95,114H,10-14,17-20,25-35,39-41H2,1-6H3,(H2,87,115)(H2,88,124)(H,99,131)(H,100,116)(H,101,126)(H,102,125)(H,103,128)(H,104,127)(H,105,133)(H,106,135)(H,107,134)(H,108,129)(H,109,132)(H,110,136)(H,111,130)(H,117,118)(H,119,120)(H,121,122)(H4,89,90,96)(H4,91,92,97)(H4,93,94,98),1H3,(H,3,4)/t44-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,70-,/m0./s1. InChi Key: CFRZREOLODHBTC-FQRYHCCPSA-N.