MC-GGFG-AM-(10Me-11F-Camptothecin)

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Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
TGM-T75134-5mg	5 mg				7 - 10 business days*		-
TGM-T75134-50mg	50 mg				7 - 10 business days*		-

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Description: MC-GGFG-AM-(10Me-11F-Camptothecin) serves as a linker-payload conjugate in the... more

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Product information "MC-GGFG-AM-(10Me-11F-Camptothecin)"

Description: MC-GGFG-AM-(10Me-11F-Camptothecin) serves as a linker-payload conjugate in the synthesis of ZW251, an antibody-drug conjugate (ADC) targeting human GPC3. ZW251 comprises a humanized IgG1 antibody linked to ZD06519, a novel camptothecin-based topoisomerase 1 inhibitor, through a maleimide-anchor and a cleavable glycyl glycyl phenylalanyl glycine (GGFG)-aminomethyl (AM) linker. ZW251 demonstrates strong affinity for GPC3 in both human and cynomolgus monkey cells, characterized by rapid internalization in GPC3-positive Hepatocellular Carcinoma (HCC) cell lines and induces bystander-mediated killing of GPC3-negative cancer cells [1]. Target: Drug-Linker Conjugates for ADC, Others

Supplier:	TargetMol
Supplier-Nr:	T75134

Properties

MW:	1038.04 D
Formula:	C51H56FN9O14

Database Information

CAS :

2873460-70-7| Matching products

Handling & Safety

Storage:	-20°C
Shipping:	+20°C (International: +4°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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