MBP146-78

MBP146-78 is an inhibitor of parasitic cGMP-dependent protein kinases (PKGs, IC50s = 1.9 and 1 nM for the E. tenella and T. gondii enzymes, respectively). It inhibits P. berghei sporozoite development into liver-stage parasites in HepG2 cells in a concentration-dependent manner. MBP146-78 (50 mg/kg) prevents P. yoelii liver infection in P. yoelii-infected mice. It increases survival time in P. berghei-infected mice when administered at a dose of 50 mg/kg twice per day for eight days. MBP146-78 (50 mg/kg two times per day) increases survival in T. gondii-infected mice and prevents secondary reinfection in the same mice.Formal Name: 4-[2-(4-fluorophenyl)-5-(1-methyl-4-piperidinyl)-1H-pyrrol-3-yl]-pyridine. CAS Number: 188343-77-3. Molecular Formula: C21H22FN3. Formula Weight: 335.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly Soluble: 0.1-1 mg/ml, Ethanol: Slightly Soluble: 0.1-1 mg/ml. SMILES: FC(C=C1)=CC=C1C2=C(C3=CC=NC=C3)C=C(C4CCN(C)CC4)N2. InChi Code: InChI=1S/C21H22FN3/c1-25-12-8-16(9-13-25)20-14-19(15-6-10-23-11-7-15)21(24-20)17-2-4-18(22)5-3-17/h2-7,10-11,14,16,24H,8-9,12-13H2,1H3. InChi Key: RBWNFHXBUDPAIO-UHFFFAOYSA-N.