Marmesin

Marmesin is a coumarin originally isolated from the mature bark of A. marmelos. Marmesin decreases proliferation and cell invasion induced by fetal bovine serum (FBS) in H1299 non-small cell lung cancer cells (NSCLCs) when used at a concentration of 10 µM. It decreases VEGF secretion in A549 and H1299 cells and inhibits capillary-like structure formation by human umbilical vein endothelial cells (HUVECs). Marmesin also decreases proliferation of U937 human leukemia cells (IC50 = 40 µM). It halts the cell cycle at the G2/M phase, increases the ratio of Bax to Bcl-2 protein, induces apoptosis, and inhibits cell migration. Marmesin reduces tumor growth in a U937 mouse xenograft model when administered at a dose of 30 mg/kg.Formal Name: (2S)-2,3-dihydro-2-(1-hydroxy-1-methylethyl)-7H-furo[3,2-g][1]benzopyran-7-one. CAS Number: 13849-08-6. Synonyms: (+)-Marmesin, (S)-Marmesin, NSC 340840. Molecular Formula: C14H14O4. Formula Weight: 246.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 50 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 2 mg/ml. lambdamax: 224, 336 nm. SMILES: O=C(C=C1)OC2=C1C=C(C[C@@H](C(O)(C)C)O3)C3=C2. InChi Code: InChI=1S/C14H14O4/c1-14(2,16)12-6-9-5-8-3-4-13(15)18-10(8)7-11(9)17-12/h3-5,7,12,16H,6H2,1-2H3/t12-/m0/s1. InChi Key: FWYSBEAFFPBAQU-LBPRGKRZSA-N. Origin: Plant/Angelica citriodora Hance.