LY487379

A positive allosteric modulator of mGluR2, selective for mGluR2 over mGluR3 in cells expressing recombinant mGluR2 or mGluR3 (IC50s = 1.7 and >10 µM, respectively), reduces MK-801-induced SOD activity in mouse frontal cortex and hippocampal homogenates, increases cognitive flexibility in the attentional set-shifting task and decreases impulsive behavior in theDRL72 schedule of food reinforcement in rats at 30 mg/kg, decreases the severity of dyskinesia and psychotic-like behaviors induced by L-DOPA in a 6-MPTP-lesioned marmoset model of Parkinson's disease at 1 or 10 mg/kg. SMILES: O=S(N(CC1=CC=CN=C1)C2=CC=C(C=C2)OC3=C(OC)C=CC=C3)(CC(F)(F)F)=O. InChi Code: InChI=1S/C21H19F3N2O4S/c1-29-19-6-2-3-7-20(19)30-18-10-8-17(9-11-18)26(14-16-5-4-12-25-13-16)31(27,28)15-21(22,23)24/h2-13H,14-15H2,1H3. InChi Key: ALMACYDZFBMGOR-UHFFFAOYSA-N