Luteolin 7-O-Glucuronide

Luteolin 7-O-glucuronide is a flavonoid that has been found in S. chloroleuca and A. pilosa, and has diverse biological activities, including antioxidant, enzyme inhibitory, and anti-inflammatory properties. It scavenges DPPH (Cay-14805) radicals in a cell-free assay (IC50 = 80.6 µM). Luteolin 7-O-Glucuronide inhibits porcine alpha-amylase and yeast alpha-glucosidase in vitro (IC50s = 61.5 and 14.7 µM, respectively). It also inhibits rat aldose reductase in vitro (IC50 = 0.7 µM) and sorbitol accumulation in isolated rat lens by 91.8% when used at a concentration of 5 µg/ml. Luteolin 7-O-glucuronide inhibits LPS-induced cytokine release from RAW 264.7 macrophages in a dose-dependent manner.Formal Name: 2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-1-benzopyran-7-yl, beta-D-glucopyranosiduronic acid. CAS Number: 29741-10-4. Synonyms: Luteolin-7-O-beta-D-glucuronide. Molecular Formula: C21H18O12. Formula Weight: 462.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly soluble, Methanol: Slightly soluble. lambdamax: 256, 353 nm. SMILES: O=C1C2=C(O)C=C(O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)C(O)=O)C=C2OC(C4=CC(O)=C(C=C4)O)=C1. InChi Code: InChI=1S/C21H18O12/c22-9-2-1-7(3-10(9)23)13-6-12(25)15-11(24)4-8(5-14(15)32-13)31-21-18(28)16(26)17(27)19(33-21)20(29)30/h1-6,16-19,21-24,26-28H,(H,29,30)/t16-,17-,18+,19-,21+/m0/s1. InChi Key: VSUOKLTVXQRUSG-ZFORQUDYSA-N. Origin: Plant/Lactuca sativa.