Lupeol

Lupeol, a dietary triterpene found in certain fruits, vegetables, and medicinal plants, has potent anti-inflammatory, anticarcinogenic, antimutagenic, and antimalarial activity. It suppresses the growth of hepatocellular carcinoma cell lines SMMC7721 and HepG2 with IC50 values of 45 and 48.5 µM and melanoma cell lines Mel 928 and Mel 1241 with IC50 values of 75 and 72 µM. At 0.76 g/kg lupeol causes a significant decrease in the blood pressure of stroke-prone hypertensive rats and reduces expression of hepatic genes involved in triglyceride and cholesterol synthesis. It also has significant anti-inflammatory effects at 50 mg/kg in a carrageenan-induced edema model, inhibiting neutrophil migration.Formal Name: (3beta)-lup-20(29)-en-3-ol. CAS Number: 545-47-1. Synonyms: Clerodol, Fagarasterol, Lupenol, Monogynol B, NSC 90487, beta-Viscol. Molecular Formula: C30H50O. Formula Weight: 426.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1.6 mg/ml, Ethanol: 1 mg/ml. SMILES: O[C@H]1CC[C@@]2(C)[C@](CC[C@]3(C)[C@]2([H])CC[C@@]4([H])[C@@]3(C)CC[C@]5(C)[C@]4([H])[C@H](C(C)=C)CC5)([H])C1(C)C. InChi Code: InChI=1S/C30H50O/c1-19(2)20-11-14-27(5)17-18-29(7)21(25(20)27)9-10-23-28(6)15-13-24(31)26(3,4)22(28)12-16-30(23,29)8/h20-25,31H,1,9-18H2,2-8H3/t20-,21+,22-,23+,24-,25+,27+,28-,29+,30+/m0/s1. InChi Key: MQYXUWHLBZFQQO-QGTGJCAVSA-N.