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Lomustine is a nitrosourea DNA alkylating agent that forms DNA interstrand crosslinks and strand breaks. It reduces tumor volume in a melanoma mouse xenograft model when administered at doses ranging from 4 to 16 mg/kg. Formulations containing lomustine have been used in the treatment of various cancers in human and veterinary medicine.Formal Name: N-(2-chloroethyl)-N'-cyclohexyl-N-nitroso-urea. CAS Number: 13010-47-4. Synonyms: CCNU, NCI C04740, NSC 79037. Molecular Formula: C9H16CIN3O2. Formula Weight: 233.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 100 mM, Ethanol: 100 mM, Water: 25 mM. lambdamax: 230 nm. SMILES: O=C(N(N=O)CCCl)NC1CCCCC1. InChi Code: InChI=1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14). InChi Key: GQYIWUVLTXOXAJ-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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