Lomefloxacin (hydrochloride)

Lomefloxacin is an orally bioavailable, broad-spectrum fluoroquinolone antibiotic. In vitro, it inhibits growth of N. gonorrhoeae, E. coli, K. pneumoniae, P. vulgaris, S. epidermidis, and M. morganii (MIC90s = 0.1, 0.39, 0.39, 0.39, 0.39, and 0.78 µg/ml, respectively). It also inhibits growth of S. aureus and methicillin-resistant S. aureus (MRSA, MIC90 = 3.13 µg/ml for both) and of H. influenzae and ampicillin-resistant H. influenzae (MIC90 = 0.1 µg/ml for both). In vivo, lomefloxacin inhibits the growth of P. mirabilis, E. coli, K. pneumoniae, and S. aureus (ED50s = 1.39, 1.45, 1.78, and 6.66 mg/kg, respectively) in mouse models of systemic infection. It inhibits bacterial DNA gyrase, thereby inhibiting DNA synthesis and bacterial growth. Formulations containing lomefloxacin have been used in the treatment of bronchitis and urinary tract bacterial infections.Formal Name: 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid, monohydrochloride. CAS Number: 98079-52-8. Synonyms: SC-47111. Molecular Formula: C17H19F2N3O3 . HCl. Formula Weight: 387.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 1 mg/ml, PBS (pH 7.2): 2 mg/ml. lambdamax: 287 nm. SMILES: CC1NCCN(C2=C(F)C=C(C(C(C(O)=O)=CN3CC)=O)C3=C2F)C1.Cl. InChi Code: InChI=1S/C17H19F2N3O3.ClH/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22,/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25),1H. InChi Key: KXEBLAPZMOQCKO-UHFFFAOYSA-N.