Lobaric Acid

Lobaric acid is a depsidone metabolite that has been isolated from Stereocaulon lichen species with antioxidant, antiproliferative, antiviral, and enzyme inhibitory activites. It scavenges superoxide radicals in a cell-free assay (IC50 = 97.9 µmol) and inhibits proliferation in a panel of leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic, and lung cancer cell lines (EC50s = 15.2-63.9 µg/ml). Lobaric acid inhibits protein tyrosine phosphatase 1B (PTP1B, IC50 = 0.87 µM for the human recombinant enzyme) and production of 12(S)-HETE (Cay-34570) by 12(S)-lipoxygenase (IC50 = 28.5 µM). In vivo, lobaric acid (250 µM) decreases lesion number, but not lesion diameter, in tobacco leaves infected with tobacco mosaic virus (TMV).Formal Name: 8-hydroxy-3-methoxy-11-oxo-1-(1-oxopentyl)-6-pentyl-11H-dibenzo[b,e][1,4]dioxepin-7-carboxylic acid. CAS Number: 522-53-2. Molecular Formula: C25H28O8. Formula Weight: 456.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: Soluble, DMSO: Soluble, Ethanol: Soluble, Methanol: Soluble. SMILES: OC(C(C(O)=O)=C1CCCCC)=CC2=C1OC(C=C(OC)C=C3C(CCCC)=O)=C3C(O2)=O. InChi Code: InChI=1S/C25H28O8/c1-4-6-8-9-15-21(24(28)29)18(27)13-20-23(15)32-19-12-14(31-3)11-16(17(26)10-7-5-2)22(19)25(30)33-20/h11-13,27H,4-10H2,1-3H3,(H,28,29). InChi Key: JHEWMLHQNRHTQX-UHFFFAOYSA-N. Origin: Fungus/Parmelia sp..