(+)-Limonene

(+)-Limonene is a monoterpene that has been found in citrus oils and Cannabis and has diverse biological activities. It is active against S. aureus, B. cereus, E. faecalis, E. coli, P. aeruginosa, K. pneumoniae, M. catarrhalis, and C. neoformans (MICs = 3-27 mg/ml). In a human BGC-823 gastric cancer nude mouse orthotopic transplantation model, (+)-limonene inhibits tumor growth by 47.6% and reduces the number of metastases in the liver, peritoneum, and other organs when administered by gastric perfusion at a dose of 15 ml/kg. Dietary administration of (+)-limonene (5 and 10% in chow) reverses doxorubicin-induced decreases in glutathione (GSH) levels in rat kidney. (+)-Limonene is toxic to cockroaches and house flies (LD50s = 700 and 90 µg/insect, respectively). Formulations containing (+)-limonene have been used as flavoring and fragrance agents, in the treatment of gallstones, heartburn, and gastroesophageal reflux disorder, as well as in the control of insects and algae.Formal Name: 1-methyl-4R-(1-methylethenyl)-cyclohexene. CAS Number: 5989-27-5. Synonyms: (+)-Dipentene, D-Limonene, (R)-(+)-Limonene. Molecular Formula: C10H16. Formula Weight: 136.2. Purity: >98%. Formulation: (Request formulation change), A neat oil. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml, Ethanol:PBS (pH 7.2)(1:2): 0.33 mg/ml. lambdamax: 203 nm. SMILES: CC1=CC[C@H](C(C)=C)CC1. InChi Code: InChI=1S/C10H16/c1-8(2)10-6-4-9(3)5-7-10/h4,10H,1,5-7H2,2-3H3/t10-/m0/s1. InChi Key: XMGQYMWWDOXHJM-JTQLQIEISA-N.