Levofloxacin (hydrate)

Levofloxacin is a fluoroquinolone antibiotic and the active stereoisomer of ofloxacin (Cay-22891). It is active against S. aureus, S. epidermidis, B. subtilis, E. coli, P. aeruginosa, and K. pneumoniae (MICs = 0.25, 0.25, 0.5, 0.03, 4, and 0.25 µg/ml, respectively). Levofloxacin inhibits S. aureus DNA gyrase and topoisomerase IV (IC50s = 8.06 and 9.81 µg/ml, respectively). It eliminates infection in rat models of endocarditis caused by methicillin-sensitive or -resistant S. aureus. Formulations containing levofloxacin have been used in the treatment of various bacterial infections.Formal Name: (3S)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, hemihydrate. CAS Number: 138199-71-0. Synonyms: MP-376. Molecular Formula: C18H20FN3O4 . 0.5H2O. Formula Weight: 370.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 25 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 299 nm. SMILES: FC1=C(N2CCN(C)CC2)C(OC[C@H](C)N3C=C(C(O)=O)C4=O)=C3C4=C1.FC5=C(N6CCN(C)CC6)C(OC[C@H](C)N7C=C(C(O)=O)C8=O)=C7C8=C5.O. InChi Code: InChI=1S/2C18H20FN3O4.H2O/c2*1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21,/h2*7-8,10H,3-6,9H2,1-2H3,(H,24,25),1H2/t2*10-,/m00./s1. InChi Key: SUIQUYDRLGGZOL-RCWTXCDDSA-N.