Leonurine

Leonurine is an alkaloid that has been found in H. leonuri and has diverse biological activities. It reduces infarct size and collagen deposition and inhibits apoptosis of cardiomyocytes in a coronary artery ligation-induced rat model of myocardial infarction when administered at a dose of 15 mg/kg per day. Leonurine (200 mg/kg per day) increases hepatic levels of superoxide dismutase (SOD) and glutathione (GSH), reduces serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, and inhibits hepatic fibrosis in a diet-induced mouse model of non-alcoholic steatohepatitis (NASH). It inhibits LPS-induced increases in TNF-alpha, IL-1beta, and IL-6 levels in the serum of broiler chicks when administered at a dose of 120 mg/kg.Formal Name: 4-hydroxy-3,5-dimethoxy-benzoic acid, 4-[(aminoiminomethyl)amino]butyl ester. CAS Number: 24697-74-3. Synonyms: SCM 198. Molecular Formula: C14H21N3O5. Formula Weight: 311.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 3 mg/ml, Ethanol: partially soluble. lambdamax: 219, 269 nm. SMILES: COC1=C(O)C(OC)=CC(C(OCCCCNC(N)=N)=O)=C1. InChi Code: InChI=1S/C14H21N3O5/c1-20-10-7-9(8-11(21-2)12(10)18)13(19)22-6-4-3-5-17-14(15)16/h7-8,18H,3-6H2,1-2H3,(H4,15,16,17). InChi Key: WNGSUWLDMZFYNZ-UHFFFAOYSA-N. Origin: Plant/Leonurus artemisia.