LD4172

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Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
TGM-T204416-10mg	10 mg	-	-	-	7 - 10 business days*		-
TGM-T204416-50mg	50 mg	-	-	-	7 - 10 business days*		-

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Description: LD4172 is a PROTAC degrader capable of degrading RIP kinase (RIPK1) with a DC50 in... more

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Product information "LD4172"

Description: LD4172 is a PROTAC degrader capable of degrading RIP kinase (RIPK1) with a DC50 in the nanomolar range. When used in combination with TNF-alpha, LD4172 can induce apoptosis in B16F10 cells. In mouse models, it demonstrates antitumor activity. (Pink: ligand for target protein, Black: linker, Blue: ligand for E3 ligase VHL). Target: RIP kinase, PROTACs. Smiles: NC1=C2C(=CN(CCCNC(CCCCCCCCCCC(N[C@H](C(=O)N3[C@H](C(N[C@@H](C)C4=CC=C(C=C4)C=5SC=NC5C)=O)C[C@@H](O)C3)[C@](C)(C)C)=O)=O)C2=NC=N1)C=6C=C7C(=CC6)N(C(CC8=CC(OC(F)(F)F)=CC=C8)=O)CC7

Supplier:	TargetMol
Supplier-Nr:	T204416

Properties

MW:	1149.37 D
Formula:	C61H75F3N10O7S

Database Information

Handling & Safety

Storage:	+4°C
Shipping:	+20°C (International: +4°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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