Laninamivir

Laninamivir is an inhibitor of influenza neuraminidases and an active metabolite of the prodrug laninamivir octanoate (Cay-40850). It inhibits the neuraminidases from influenza A H1N1, H2N2, and H3N2 strains (mean IC50s = 2.49, 11.4, and 16.7 nM, respectively) and influenza B Victoria and Yamagata strains (mean IC50s = 18.9 nM for both). Intranasal administration of laninamivir (69 µg/kg) increases survival in a mouse model of lethal influenza H1N1 infection. Formulations containing laninamivir have been used in the prevention of influenza.Formal Name: 5-(acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-7-O-methyl-D-glycero-D-galacto-non-2-enonic acid. CAS Number: 203120-17-6. Synonyms: R-125489. Molecular Formula: C13H22N4O7. Formula Weight: 346.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: PBS (pH 7.2): Sparingly soluble: 1-10 mg/ml. SMILES: O=C(C)N[C@H]1[C@@]([C@H](OC)[C@H](O)CO)([H])OC(C(O)=O)=C[C@@H]1NC(N)=N. InChi Code: InChI=1S/C13H22N4O7/c1-5(19)16-9-6(17-13(14)15)3-8(12(21)22)24-11(9)10(23-2)7(20)4-18/h3,6-7,9-11,18,20H,4H2,1-2H3,(H,16,19)(H,21,22)(H4,14,15,17)/t6-,7+,9+,10+,11+/m0/s1. InChi Key: QNRRHYPPQFELSF-CNYIRLTGSA-N.