Lamevudine

Lamevudine is an antiviral. It selectively inhibits wild-type hepatitis C virus (HCV) non-structural protein 5BDelta55 (NS5BDelta55) over NS5BDelta55 harboring a serine-to-threonine substitution at residue 282 (NS5BDelta55S282T, IC50s = 0.07 and 25 µM, respectively). Lamevudine selectively inhibits replication of HCV replicons in wild-type HBI10A cells over HBI10A cells expressing NS5BDelta55S282T (EC50s = 0.3 and 10.1 µM, respectively). In vitro, it reduces the cytopathic effect of positive-strand RNA viruses in the families Flaviviridae (EC50s = 0.3-15 µM) and Picornaviridae (EC50s = 0.5-5.9 µM) but not viruses of the negative-strand RNA virus family Paramyxoviridae. It inhibits the cytopathic effect and reduces virus yields of the Zika virus strain MR766 in infected Vero cells (EC50s = 20 and 9.6 µM, respectively). It also reduces serum viral load and delays virus-induced morbidity and mortality in AG129 mice, which lack Ifn-alpha/beta and Ifn-gamma receptors, infected with Zika virus when administered at a dose of 50 mg/kg per day.Formal Name: 7-(2-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine. CAS Number: 443642-29-3. Synonyms: 7-Deaza-2'-C-methyladenosine, MK-0608. Molecular Formula: C12H16N4O4. Formula Weight: 280.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly soluble: 0.1-1 mg/ml. SMILES: O[C@H]1[C@](O)(C)[C@H](N2C3=NC=NC(N)=C3C=C2)O[C@@H]1CO. InChi Code: InChI=1S/C12H16N4O4/c1-12(19)8(18)7(4-17)20-11(12)16-3-2-6-9(13)14-5-15-10(6)16/h2-3,5,7-8,11,17-19H,4H2,1H3,(H2,13,14,15)/t7-,8-,11-,12-/m1/s1. InChi Key: IRZRJANZDIOOIF-GAJNKVMBSA-N.