Lalistat 1

Lalistat 1 is an inhibitor of lysosomal acid lipase (LAL, IC50 = 68 nM using purified human LAL). It is selective for LAL over human pancreatic and bovine milk lipoprotein lipases up to a concentration of 10 µM. Lalistat 1 (0.01-10 µM) reduces cholesterol accumulation in lysosome-like storage organelles in GM03123 human fibroblast cells deficient in NPC1, a membrane protein found in late endosomes, in a concentration-dependent manner but has little effect on cholesterol accumulation in NPC1-deficient CHO cells.Formal Name: 4-morpholinecarboxylic acid, 4-(1-piperidinyl)-1,2,5-thiadiazol-3-yl ester. CAS Number: 501104-16-1. Molecular Formula: C12H18N4O3S. Formula Weight: 298.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml, Ethanol:PBS(pH 7.2) (1:5): 0.16 mg/ml. lambdamax: 302 nm. SMILES: O=C(N1CCOCC1)OC2=NSN=C2N3CCCCC3. InChi Code: InChI=1S/C12H18N4O3S/c17-12(16-6-8-18-9-7-16)19-11-10(13-20-14-11)15-4-2-1-3-5-15/h1-9H2. InChi Key: XAWUWPUYJUOUOF-UHFFFAOYSA-N.