L67

L67 is a competitive inhibitor of DNA ligases I and III (IC50s = 10 and 10 µM for human DNA ligase I and human ligase IIIbeta). It blocks DNA binding (Ki = 10 µM), increasing the cytotoxicity of DNA-damaging agents. It also inhibits mitochondrial DNA ligase IIIalpha and induces the production of reactive oxygen species (ROS) and apoptosis in cancerous, but not non-malignant, cells. It does not inhibit DNA ligase IV or T4 DNA ligase at concentrations up to 100 µM.Formal Name: N-(3,5-dibromo-4-methylphenyl)-glycine, 2-[(2-hydroxy-5-nitrophenyl)methylene]hydrazide. CAS Number: 325970-71-6. Molecular Formula: C16H14Br2N4O4. Formula Weight: 486.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml. lambdamax: 217, 280 nm. SMILES: OC1=CC=C([N+]([O-])=O)C=C1/C=N/NC(CNC2=CC(Br)=C(C)C(Br)=C2)=O. InChi Code: InChI=1S/C16H14Br2N4O4/c1-9-13(17)5-11(6-14(9)18)19-8-16(24)21-20-7-10-4-12(22(25)26)2-3-15(10)23/h2-7,19,23H,8H2,1H3,(H,21,24)/b20-7+. InChi Key: KFEPVFJQVOMODD-IFRROFPPSA-N.