L-Cysteinesulfinic Acid (hydrate)

L-Cysteinesulfinic acid is an excitatory amino acid and agonist of metabotropic glutamate receptors (mGluRs). It increases intracellular inositol phosphate levels in CHO cells expressing mGluR1, mGluR5, or mGluR8 (EC50s = 120, 30, and 110 µM, respectively) and inhibits forskolin-induced cAMP production in CHO cells expressing mGluR2 or mGluR6 and hamster kidney cells expressing mGluR4 (EC50s = 100, 100, and 2,000 µM, respectively). It selectively binds to mGluR1alpha (Ki = 3,510 nM) over adrenergic, dopamine, histamine, muscarinic, nicotinic, or serotonin receptors (Kis = >10,000 nM for all). L-Cysteinesulfinic acid (1 mM) decreases mean arterial blood pressure and heart rate in rats when microinjected into the nucleus tractus solitarius (NTS). L-Cysteinesulfinic acid can be formed via oxidation of L-cysteine by reactive oxygen species (ROS), and conversion of cysteine to L-cysteinesulfinic acid in cysteine-containing peptide probes has been used to measure oxidative stress.Formal Name: 3-sulfino-L-alanine, monohydrate. CAS Number: 207121-48-0. Synonyms: L-CSA. Molecular Formula: C3H7NO4S . H2O. Formula Weight: 171.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 10 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: OC([C@@H](N)CS(O)=O)=O.O. InChi Code: InChI=1S/C3H7NO4S.H2O/c4-2(3(5)6)1-9(7)8,/h2H,1,4H2,(H,5,6)(H,7,8),1H2/t2-,/m0./s1. InChi Key: YQIXTMZYGQXTCZ-DKWTVANSSA-N.