L-Alanosine

L-Alanosine is an antibiotic derived from bacterium S. alanosinicus with antineoplastic activity in cells deficient in methylthioadenosine phosphorylase (MTAP) (mean IC50 = 4.8 µM and 10 µM in T-ALL and CAK-1 cells, respectively). L-Alanosine inhibits adenylosuccinate synthetase to disrupt de novo purine biosynthesis, inhibiting cellular metabolism in MTAP-deficient tumor cells.Formal Name: 3-(hydroxynitrosoamino)-L-alanine. CAS Number: 5854-93-3. Synonyms: NSC 153353, NSC 529469, SDX-102. Molecular Formula: C3H7N3O4. Formula Weight: 149.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: 100 mM HCl: 1 mg/ml, 100 mM NaOH: 1 mg/ml, Water: 1 mg/ml. lambdamax: 250 nm. SMILES: ON(N=O)C[C@H](N)C(O)=O. InChi Code: InChI=1S/C3H7N3O4/c4-2(3(7)8)1-6(10)5-9/h2,10H,1,4H2,(H,7,8)/t2-/m0/s1. InChi Key: MLFKVJCWGUZWNV-REOHCLBHSA-N.