Kuwanon C

Kuwanon C is a prenylated flavone originally isolated from M. alba that has diverse biological activities, including antioxidant, antibacterial, antiproliferative, and neuroprotective properties. It scavenges DPPH (Cay-14805) radicals in a cell-free assay (EC50 = 72.99 µg/ml). It is active against E. coli, S. typhimurium, S. epidermis, and S. aureus (MICs = 10, 25, 6.25, and 6.25 µg/ml, respectively) and inhibits the growth of P388 mouse lymphoma cancer cells (IC50 = 14 µg/ml). Kuwanon C (30 mg/kg) improves motor coordination in a rotarod test and decreases neuronal loss in the substantia nigra pars compacta in a mouse model of MPTP-induced Parkinson's disease.Formal Name: 2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-3,8-bis(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one. CAS Number: 62949-79-5. Synonyms: Mulberrin. Molecular Formula: C25H26O6. Formula Weight: 422.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. lambdamax: 264 nm. SMILES: O=C1C2=C(C=C(C(C/C=C(C)\C)=C2OC(C3=C(O)C=C(O)C=C3)=C1C/C=C(C)\C)O)O. InChi Code: InChI=1S/C25H26O6/c1-13(2)5-8-17-20(28)12-21(29)22-23(30)18(9-6-14(3)4)24(31-25(17)22)16-10-7-15(26)11-19(16)27/h5-7,10-12,26-29H,8-9H2,1-4H3. InChi Key: UWQYBLOHTQWSQD-UHFFFAOYSA-N. Origin: Plant/Morus root.