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| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| Cay41263-1 | 1 mg | - |
6 - 10 business days* |
265.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Klotho-derived peptide 6 (KP6) is a synthetic peptide fragment that corresponds to amino acids... more
Product information "Klotho-derived Peptide 6 (acetate)"
Klotho-derived peptide 6 (KP6) is a synthetic peptide fragment that corresponds to amino acids 186-215 of the anti-aging protein Klotho. It inhibits Wnt1-induced increases in fibronectin and alpha-smooth muscle actin (alpha-SMA) levels in HKC-8 human proximal tubular cells. KP6 (5 µg/ml) also inhibits Wnt3a-induced activation of beta-catenin in a reporter assay using HEK293T cells. In vivo, KP6 (1 mg/kg) increases survival and decreases urine albumin levels, renal hypertrophy, and glomerular injury in a mouse model of diabetic kidney disease induced by streptozotocin (STZ, Cay13104), advanced oxidation protein products, and unilateral nephrectomy.
| Keywords: | Klotho (186-215) (human), KP6, L-glutaminyl-L-prolyl-L-valyl-L-valyl-L-threonyl-L-leucyl-L-tyrosyl-L-histidyl-L-tryptophyl-L-alpha-aspartyl-L-leucyl-L-prolyl-L-glutaminyl-L-arginyl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-alanyl-L-tyrosylglycylglycyl-L-tr |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 41263 |
Properties
| Application: | Wnt/beta-catenin signaling inhibitor |
| MW: | 3491.83 D |
| Formula: | C159H232N46O44 . XC2H4O2 |
| Purity: | >95% |
| Format: | Solid |
Database Information
| KEGG ID : | K14756 | Matching products |
| UniProt ID : | Q9UEF7 | Matching products |
| Gene ID : | GeneID 9365 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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